In 2014, Bigagli E, et al. published a scientific study that examined the gene expression of RWPE-1 cells (prostate epithelial cells) when treated with Apis mellifica, a homeopathic remedy, in Mother Tincture – TM form at potencies of 3C, 5C, and 7C for a span of 24 hours.
Commonly used by homeopaths, Apis mellifica is derived from bees and their venom.”
This treatment is frequently utilized for various forms of allergy, oedema, redness, pain, and inflammation.
The scientists examined the genetic expression of cytokines and inflammatory processes, as well as antioxidant responses and protease degradation.
“They not only discovered clear effects , but also observed
varying outcomes between the mother tincture and potentiated dilutions.”
For instance, the mother tincture enhanced the expression of the IL1b gene, which produces a strong pro-inflammatory cytokine. In contrast, the potentised remedies lessened the expression of this gene.
As per the research authors, Apis mellifica TM and its 3C, 5C, and 7C dilutions had an impact on numerous genes. Through cluster analysis, they identified clusters of up- or down-regulated genes that exhibited similar expression patterns across treatments.
Additionally, certain genes showed contrasting regulation profiles in low and high dilutions of Apis mellifica, indicating a potential hormetic response.
Specifically, genes associated with cytokine production, inflammation, antioxidant defense, and proteasome breakdown exhibited varied and occasionally opposing levels of expression in TM or Apis mellifica 3C, 5C and 7C dilutions. This was further supported by RT-PCR analysis of five chosen genes (IL1β, CD46, ATF1, UBE2Q2, and MT1X).
Based on their findings, the researchers determined that Apis mellifica TM can alter gene expression in human cells and also has a suppressive impact on processes regulating inflammation. Additionally, even highly diluted dynamic dilutions (3C, 5C and 7C) continued to exhibit significant effects on genes related to inflammation and oxidative stress.
Access the complete scientific article here.
Source: https://pubmed.ncbi.nlm.nih.gov/24685417/
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